Includes bibliographical references and indexes.

I: Fuel metabolism -- Metabolic fuels and dietary components -- The fed or absorptive state -- Fasting -- II: Chemical and biologic foundations of biochemistry -- Water, acids, bases, and buffers -- Structures of the major compounds of the body -- Amino acids in proteins -- Structure-function relationships in proteins -- Enzymes as catalysts -- Regulation of enzymes -- Relationship between cell biology and biochemistry -- Cell signaling by chemical messengers -- III: Gene expression and the synthesis of proteins -- Structure of the nucleic acids -- Synthesis of DNA -- Transcription: synthesis of RNA -- Translation: synthesis of proteins -- Regulation of gene expression -- Use of recombinant DNA techniques in medicine -- The molecular biology of cancer -- IV: Carbohydrate metabolism, fuel oxidation, and the generation of adenosine triphosphate -- Basic concepts in the regulation of fuel metabolism by insulin, glucagon, and other hormones -- Cellular bioenergetics: adenosine triphosphate and O2 -- Digestion, absorption, and transport of carbohydrates -- Generation of adenosine triphosphate from glucose, fructose, and galactose: glycolysis -- Tricarboxylic acid cycle -- Oxidative phosphorylation and mitochondrial function -- Oxygen toxicity and free-radical injury -- Formation and degradation of glycogen -- Pentose phosphate pathway and the synthesis of glycosides, lactose, glycoproteins, and glycolipids -- Gluconeogenesis and maintenance of blood glucose levels -- V: Lipid metabolism -- Digestion and transport of dietary lipids -- Oxidation of fatty acids and ketone bodies -- Synthesis of fatty acids, triacylglycerols, and the major membrane lipids -- Cholesterol absorption, synthesis, metabolism, and fate -- Metabolism of ethanol -- Integration of carbohydrate and lipid metabolism -- VI: Nitrogen metabolism -- Protein digestion and amino acid absorption -- Fate of amino acid nitrogen: urea cycle -- Synthesis and degradation of amino acids -- Tetrahydrofolate, vitamin B12, and S-adenosylmethionine -- Purine and pyrimidine metabolism -- Intertissue relationships in the metabolism of amino acids VII: tissue metabolism -- Actions of hormones that regulate fuel metabolism -- The biochemistry of erythrocytes and other blood cells -- Blood plasma proteins, coagulation, and fibrinolysis -- Liver metabolism -- Metabolism of muscle at rest and during exercise -- Metabolism of the nervous system -- The extracellular matrix and connective tissue.