Includes bibliographical references and index

Modern cancer drug discovery: integrating targets, technologies, and treatments for personalized medicine / Paul Workman, Ian Collins -- Pharmacogenomics and personalized medicines in cancer treatment / Wei-Peng Yong, Ross Soo, Federico Innocenti -- Natural product chemistry and cancer drug discovery / Donna M. Huryn, Peter Wipf -- Structural biology and anticancer drug design / Puja Pathuri, David Norton, Henriette Willems, Dominic Tisi, Harren Jhoti -- Temozolomide: from cytotoxic to molecularly targeted agent / Malcom F.G. Stevens -- Temozolomide: patents and the perils of invention / Malcolm F.G. Stevens -- A new generation of cell-targeted drugs for cancer treatment / Paola B. Arimondo, Nicolas Guilbaud, Christian Bailly -- Inhibition of DNA repair as a therapeutic target / Stephany Veuger, Nicola J. Curtin -- Exploiting cancer dependence on molecular chaperones: HSP90 inhibitors past, present, and future / Swee Sharp, Keith Jones, Paul Workman -- Inhibitors of tumor angiogenesis / Adrian L. Harris, Daniele Generali -- The renaissance of CYP17 inhibitors for the treatment of prostate cancer / Qingzhong Hu, Rolf W. Hartmann -- Apoptosis in cancer: mechanisms, deregulation, and therapeutic targeting / Zahid H. Siddik -- Targeting the MDM2-p53 protein-protein interaction: design, discovery, and development of novel anticancer agents / Ian R. Hardcastle -- Targeting altered metabolism- emerging cancer therapeutic strategies / Minsuh Seo, Robert Blake Crochet, Yong-Hwan Lee -- Inhibitors of the phosphatidylinositol 3-kinase pathway / William A. Denny and Gordon W. Rewcastle -- Antibody-drug conjugates delivering DNA cytotoxics / John A. Hartley -- Inhibition of telomerase: promise, progress, and potential pitfalls / Christopher G. Tomlinson, Scott B. Cohen, Tracy M. Bryan -- Targeting B-RAF: the discovery and development of B-RAF inhibitors / Philip A. Harris -- Failure modes in anticancer drug discovery and development / Richard A. Walgren, Christopher A. Slapak -- Anticancer drug registration and regulation: current challenges and possible solutions / Erling Donnelly, Silvia Chioato, David Taylor